The nature of the reparative process of tissues in the cesarean section area in pregnant women with a comorbid 

Alina E. Markina, Applicant of the sub-department of faculty surgery with courses in topographic anatomy and operative surgery, urology and pediatric surgery, Medical Institute, Ogarev Mordovia State University (68 Bolshevistskaya street, Saransk, Russia)
Aleksey P. Vlasov, Doctor of medical sciences, professor, head of the sub-department of faculty surgery with courses in topographic anatomy and operative surgery, urology and pediatric surgery, Medical Institute, Ogarev Mordovia State University (68 Bolshevistskaya street, Saransk, Russia), vap.61@yandex.ru
Nina Yu. Leschankina, Doctor of medical sciences, associate professor, professor of the sub-department of hospital therapy, Medical Institute, Ogarev Mordovia State University (68 Bolshevistskaya street, Saransk, Russia), bream25@yandex.ru
Darya A. Kapitanova, Student, Medical Institute, Ogarev Mordovia State University (68 Bolshevistskaya street, Saransk, Russia), darjakap@yandex.ru

Background. At this moment, the number of cesarean section deliveries has in creased, which raises the risk of postoperative complications, especially in patients with a comorbid background. The aim of the work was to establish the features of the reparative process of the tissues of the cesarean section area with a different comorbid background (preeclampsia, obesity). Material and methods. The analysis was performed on 102 pregnant women, that underwent cesarean section. Group 1 (25) – pregnant women without comorbid pathology, group 2 (27) – women with 2nd degree of obesity; group 3 (22) – with 3rd degree of obesity; group 4 (28) – with moderate and severe preeclampsia. The healing process of laparotomy wound tissues was evaluated. The obtained digital data was pro cessed by the method of variation statistics. Results. In pregnant women with preeclampsia and obesity, especially with grade 3, the healing of abdominal wall tissues in the cesarean section area in the early postoperative period proceeds at a slow tempo. According to the assessment of the cytological material, the prolongation of the inflammatory phase and its delayed transition to the reparative phase have been established. This has been confirmed by clinical tests. In vitro studies have established the effect of plasma from pregnant women with preeclampsia on the metabolic activity and regenerative potential of dermal fibroblast cultures. Conclusion. In women in labor with moderate and severe preeclampsia, as well as with third-degree obesity who underwent cesarean delivery, the reparative regeneration of laparotomy wound tissues gone slowly and is manifested in the early stages by a significant decrease in the degenerative-degenerative index, slowing down the transformation of poly blasts into tissue forms. In vitro studies have established the effect of plasma from pregnant women with preeclampsia on the metabolic activity and regenerative potential of dermal fi broblast cultures; no significant differences were found in comorbid obesity.

preeclampsia, obesity, cesarean section, tissue healing, dermal fibroblasts

Markina A.E., Vlasov A.P., Leshchankina N.Yu., Kapitanova D.A., Kormishkin A.E., Vlasova T.I. The nature of the reparative process of tissues in the cesarean section area in pregnant women with a comorbid. Izvestiya vysshikh uchebnykh zavedeniy. Povolzhskiy region. Meditsinskie nauki = University proceedings. Volga region. Medical sciences. 2025;(2):154–165. (In Russ.). doi: 10.21685/2072-3032-2025-2-14